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KMID : 0358819820090020123
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1982 Volume.9 No. 2 p.123 ~ p.128
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EXPERIMENTAL STUDY ON EFFECT OF NEURAL REGULATION FOR FLAP SURVIVAL IN RATS
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Kim Dong-Chul
Park Beyoung-Yun
Lee Young-Ho
You Jae-Duk
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Abstract
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Numerous papers concerning improved flap survival have been published in the field of Plastic Surgery. With the suggestions that loss of endogenous neural regulation accounts for flap necrosis, many authors attemped to improve flap survival with pharmacological treatment on neural receptor sites. It would be expected that investigation for effects on functional endogenous neural regulation to flap survival may further advance exogenous neural manipulation for improvement of flap survival.
In this study, the effects of functional neural regulation on flap survival was observed on the experimentally made innervated and denervated flaps in rats. Also observed was the effects on flap survival by administration to sympathetic neuronal blocking agent(Guanethidine) and parasympathetic postganglionic blocking agent(Atropine). In results, the innervated flaps were survived significantly more than the denervated flaps. The blocking of sympathetic innervation showed flap necrosis more than the innervated flaps and so as the parasympathetic blocking did the same results.
In conclusion, the loss of the endogenous neural regulation on flap survival is directly related to flap necrosis, and adrenergic regulation as well as cholinergic regulation have a significant role in flap survival
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KEYWORD
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